COMBINATION OF FARNESYL-TRANSFERASE INHIBITION WITH KRAS G12D TARGETING BREAKS DOWN THERAPEUTIC RESISTANCE IN PANCREATIC CANCER

Combination of farnesyl-transferase inhibition with KRAS G12D targeting breaks down therapeutic resistance in pancreatic cancer

Pancreatic adenocarcinoma is one of the deadliest forms of cancer with no effective therapeutic options.A KRAS mutation can be found in up to 90% of all pancreatic tumors, making it a promising therapeutic target.The introduction of new KRAS inhibitors has been a milestone in the history of KRAS mutant tumors; however, therapeutic resistance limits

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A sensitivity study of Surface Wind simulations over Coastal Ghana to selected Time Control and Nudging options in the Weather Research and Forecasting Model

Over the years, the Weather Research and Forecasting Model (WRF) has been gaining popularity as a low-cost alternative source of data for wind resource assessments.This paper investigates the impact of selected time control, and nudging options on wind simulations in WRF.We conducted 15 numerical bee by bonnie and neil experiments, combining 5 simu

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Spatiotemporal analysis of the future carbon footprint of solar electricity in the United States by a dynamic life cycle assessment

Summary: Solar photovoltaics (PVs) installation would increase 20-fold by 2050; however, galaxy s23 ultra otterbox defender case considerable greenhouse gas (GHG) emissions are generated during the cradle-to-gate production, with spatiotemporal variances depending on the grid emission.Thus, a dynamic life cycle assessment (LCA) model was developed

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